Propranolol/HCTZ is a combination drug used for the treatment of high blood pressure. It contains propranolol which is a beta blocker and hydrochlorothiazide which is a diuretic. Propranolol has a chemical name of (RS)-1-(isopropylamino)-3-(1-naphthyloxy) propan-2-ol. Its molecular formula is C16H21NO2 and it has a molecular weight of 259.34. It works by blocking the beta adrenergic receptors on the heart muscles and blood vessels. When stress hormones like adrenaline bind to these receptors, it causes increased heart beat, increase in force of heart beats, high blood pressure. By blocking these receptors, beta blockers cause vasodilation, increase blood supply to the heart, improve cardiac output and reduce blood pressure. The chemical name for hydrochlorothiazide: 6-chloro-1, 1-dioxo-3, 4-dihydro-2H-1, 2, 4-benzothiadiazine-7-sulfonamide. It has a molecular formula of C7H8ClN3O4S2 and its molecular weight is 297.74. It helps in the elimination of excess salt and water from the body through urination. In this way it helps prevent water retention and reduces blood volume which in turn contributes to lower blood pressure. This combination drug is available through prescription only. It is available in the form of extended release capsules and immediate release tablets. Take the form and dose that is recommended by your doctor. Initially you may experience some side effects like headaches, lightheadedness, nausea but they fade as the body adjusts to the medication.
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